Gregson, S.J., Howard, P.W., Barcella, S., Nakamya, A., Jenkins, T.C., Kelland, L.R. and Thurston, D.E. (2000) Effect of C2/C3-endo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines. Bioorganic and Medicinal Chemistry Letters, 10 (16). pp. 1849-1851. 10.1016/S0960-894X(00)00350-4.
Full text not available from this repository.
DOI: 10.1016/S0960-894X(00)00350-4
Abstract
A series of novel C2,C3-endo unsaturated pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) has been synthesised via cleavage of the N10-Alloc protecting group from appropriate precursors. Biophysical and biological evaluations show that the presence of C2/C3-endo unsaturation in the PBD C-ring enhances both DNA-binding reactivity and in vitro cytotoxic potency.
| Item Type: | Article |
|---|---|
| Departments, units and centres: | Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry |
| ID Code: | 2925 |
| Journal or Publication Title: | Bioorganic and Medicinal Chemistry Letters |
| Deposited By: | Library Staff |
| Deposited On: | 09 Mar 2012 09:52 |
| Last Modified: | 09 Mar 2012 09:52 |
Statistics
Item downloaded times since 09 Mar 2012 09:52.
Repository Staff Only: Item control page
School of Pharmacy Staff Only: Edit a copy to replace this item