Effect of C2-exo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines.

Gregson, S.J., Howard, P.W., Corcoran, K.E, Barcella, S., Yasin, M.M., Hurst, A.A., Jenkins, T.C., Kelland, L.R. and Thurston, D.E. (2000) Effect of C2-exo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines. Bioorganic and Medicinal Chemistry Letters, 10 (16). pp. 1845-1847. 10.1016/S0960-894X(00)00351-6.

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DOI: 10.1016/S0960-894X(00)00351-6

Abstract

A series of novel C2-exo unsaturated pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) has been synthesised via a versatile pro-C2 ketone precursor. C2-exo-unsaturation enhances both DNA-binding reactivity and in vitro cytotoxic potency.

Item Type:Article
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:2926
Journal or Publication Title:Bioorganic and Medicinal Chemistry Letters
Deposited By:Library Staff
Deposited On:09 Mar 2012 09:56
Last Modified:09 Mar 2012 09:56

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