Gregson, S.J., Howard, P.W., Thurston, D.E., Jenkins, T.C. and Kelland, L.R. (1999) Synthesis of a novel C2/C2′-exo unsaturated pyrrolobenzodiazepine cross-linking agent with remarkable DNA binding affinity and cytotoxicity. Chemical Communications (9). pp. 797-798. 10.1039/A809791G.
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DOI: 10.1039/A809791G
Abstract
A C2/C2′-exo unsaturated pyrrolobenzodiazepine dimer 1 has been synthesised which is cytotoxic at the picomolar level and has remarkable covalent DNA binding affinity, raising the melting temperature of duplex-form calf thymus DNA by 34°C after 18 h incubation.
| Item Type: | Article |
|---|---|
| Departments, units and centres: | Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry |
| ID Code: | 2927 |
| Journal or Publication Title: | Chemical Communications |
| Deposited By: | Library Staff |
| Deposited On: | 09 Mar 2012 10:22 |
| Last Modified: | 09 Mar 2012 10:22 |
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