Synthesis of a novel C2/C2′-exo unsaturated pyrrolobenzodiazepine cross-linking agent with remarkable DNA binding affinity and cytotoxicity

Gregson, S.J., Howard, P.W., Thurston, D.E., Jenkins, T.C. and Kelland, L.R. (1999) Synthesis of a novel C2/C2′-exo unsaturated pyrrolobenzodiazepine cross-linking agent with remarkable DNA binding affinity and cytotoxicity. Chemical Communications (9). pp. 797-798. 10.1039/A809791G.

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DOI: 10.1039/A809791G

Abstract

A C2/C2′-exo unsaturated pyrrolobenzodiazepine dimer 1 has been synthesised which is cytotoxic at the picomolar level and has remarkable covalent DNA binding affinity, raising the melting temperature of duplex-form calf thymus DNA by 34°C after 18 h incubation.

Item Type:Article
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:2927
Journal or Publication Title:Chemical Communications
Deposited By:Library Staff
Deposited On:09 Mar 2012 10:22
Last Modified:09 Mar 2012 10:22

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