A novel series of DNA triple helix-binding ligands.

Fox, K.R., Thurston, D.E., Jenkins, T.C., Varvaresou, A., Tsotinis, A. and Siatra-Papastaikoudi, T. (1996) A novel series of DNA triple helix-binding ligands. Biochemical and Biophysical Research Communications, 224 (3). pp. 717-720. 10.1006/bbrc.1996.1089.

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DOI: 10.1006/bbrc.1996.1089


We have examined the effect of a series of substituted imidazothioxanthones on the stability of an intermolecular DNA triple helix by DNase I footprinting. We find that several of these compounds promote the formation of a complex between T5C5 and the target site A6G6.C6T6, suggesting that they bind specifically to triplex DNA. The only inactive derivative lacked a protonatable function in the side chain, suggesting that this is an essential feature for triplex stabilization. These compounds, which are amongst the first triplex-binding ligands which possess an uncharged chromophore, are selective for the T.AT rather than the C+.GC triplet.

Item Type:Article
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:2929
Journal or Publication Title:Biochemical and Biophysical Research Communications
Deposited By:Library Staff
Deposited On:09 Mar 2012 10:42
Last Modified:09 Mar 2012 10:42


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