Design and synthesis of a novel epoxide-containing pyrrolo[2,1-c][1,4]benzodiazepine (PBD) via a new cyclization procedure

Wilson, S.C., Howard, P.W. and Thurston, D.E. (1995) Design and synthesis of a novel epoxide-containing pyrrolo[2,1-c][1,4]benzodiazepine (PBD) via a new cyclization procedure. Tetrahedron Letters, 36 (35). pp. 6333-6336. 10.1016/0040-4039(95)01224-6.

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DOI: 10.1016/0040-4039(95)01224-6

Abstract

The synthesis of a potential DNA-crosslinking pyrrolo[2,1-c]-[1,4]benzodiazepine (PBD) substituted at the C8-position with a 2,3-epoxypropaneoxy moiety using a new cyclization procedure is described.

Item Type:Article
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:2931
Journal or Publication Title:Tetrahedron Letters
Deposited By:Library Staff
Deposited On:09 Mar 2012 10:51
Last Modified:09 Mar 2012 10:51

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