New approaches to pyrrolo[2,1-c][1,4]benzodiazepines: synthesis, DNA-binding and cytotoxicity of DC-81

Subhas Bose, D, Jones, G.B. and Thurston, D.E. (1992) New approaches to pyrrolo[2,1-c][1,4]benzodiazepines: synthesis, DNA-binding and cytotoxicity of DC-81. Tetrahedron, 48 (40). p. 751. 10.1016/S0040-4020(01)88134-5.

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DOI: 10.1016/S0040-4020(01)88134-5

Abstract

Two routes to the naturally occurring DNA-binding antitumour antibiotic DC-81 are described, one of which involves a novel cyclization process based on acid resin. The second route involves the synthesis of a new compound, 6-nitrovanillic acid, a key A-ring component of many naturally occurring PBDs. These routes have provided a sufficient quantity of DC-81 to allow complete characterization and evaluation in DNA-binding and in vitro cytotoxicity studies.

Item Type:Article
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:2934
Journal or Publication Title:Tetrahedron
Deposited By:Library Staff
Deposited On:09 Mar 2012 12:55
Last Modified:09 Mar 2012 12:55

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