Subhas Bose, D, Jones, G.B. and Thurston, D.E. (1992) New approaches to pyrrolo[2,1-c][1,4]benzodiazepines: synthesis, DNA-binding and cytotoxicity of DC-81. Tetrahedron, 48 (40). p. 751. 10.1016/S0040-4020(01)88134-5.
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DOI: 10.1016/S0040-4020(01)88134-5
Abstract
Two routes to the naturally occurring DNA-binding antitumour antibiotic DC-81 are described, one of which involves a novel cyclization process based on acid resin. The second route involves the synthesis of a new compound, 6-nitrovanillic acid, a key A-ring component of many naturally occurring PBDs. These routes have provided a sufficient quantity of DC-81 to allow complete characterization and evaluation in DNA-binding and in vitro cytotoxicity studies.
| Item Type: | Article |
|---|---|
| Departments, units and centres: | Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry |
| ID Code: | 2934 |
| Journal or Publication Title: | Tetrahedron |
| Deposited By: | Library Staff |
| Deposited On: | 09 Mar 2012 12:55 |
| Last Modified: | 09 Mar 2012 12:55 |
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