Cytotoxic and haemolytic steroidal glycosides from the Caribbean sponge Pandaros acanthifolium.

Regalado, E.L., Turk, T., Tasdemir, D., Gorjanc, M., Kaiser, M., Thomas, O.P., Fernández, R. and Amade, P. (2011) Cytotoxic and haemolytic steroidal glycosides from the Caribbean sponge Pandaros acanthifolium. Steroids, 76 (12). pp. 1389-1396. 10.1016/j.steroids.2011.07.010.

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DOI: 10.1016/j.steroids.2011.07.010

Abstract

Six new steroidal saponins, pandarosides K-M (1-3) and their methyl esters (4-6), were isolated as minor components, after a careful chemical reinvestigation of the Caribbean sponge Pandaros acanthifolium. Their structures were established on the basis of spectroscopic analyses and comparison with the data obtained from previous metabolites of this family. All new compounds showed moderate to weak activity against four parasitic protozoa. Additionally, these compounds and previously reported pandarosides and acanthifoliosides were tested on three human tumour cell lines, and their haemolytic and liposome permeabilizing activity were assessed. Two pandarosides exhibited moderate to strong cytotoxic effect, while three acanthifoliosides showed strong haemolytic activity.

Item Type:Article
Uncontrolled Keywords:Antiprotozoal; Cytotoxic; Haemolytic; Marine sponge; Pandaros; Steroidal glycosides
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:2949
Journal or Publication Title:Steroids
Deposited By:Library Staff
Deposited On:09 Mar 2012 16:08
Last Modified:09 Mar 2012 16:09

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