Regalado, E.L., Turk, T., Tasdemir, D., Gorjanc, M., Kaiser, M., Thomas, O.P., Fernández, R. and Amade, P. (2011) Cytotoxic and haemolytic steroidal glycosides from the Caribbean sponge Pandaros acanthifolium. Steroids, 76 (12). pp. 1389-1396. 10.1016/j.steroids.2011.07.010.
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Six new steroidal saponins, pandarosides K-M (1-3) and their methyl esters (4-6), were isolated as minor components, after a careful chemical reinvestigation of the Caribbean sponge Pandaros acanthifolium. Their structures were established on the basis of spectroscopic analyses and comparison with the data obtained from previous metabolites of this family. All new compounds showed moderate to weak activity against four parasitic protozoa. Additionally, these compounds and previously reported pandarosides and acanthifoliosides were tested on three human tumour cell lines, and their haemolytic and liposome permeabilizing activity were assessed. Two pandarosides exhibited moderate to strong cytotoxic effect, while three acanthifoliosides showed strong haemolytic activity.
|Uncontrolled Keywords:||Antiprotozoal; Cytotoxic; Haemolytic; Marine sponge; Pandaros; Steroidal glycosides|
|Departments, units and centres:||Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry|
|Journal or Publication Title:||Steroids|
|Deposited By:||Library Staff|
|Deposited On:||09 Mar 2012 16:08|
|Last Modified:||09 Mar 2012 16:09|
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