Antiprotozoal activity of Melampyrum arvense and its metabolites.

Kirmizibekmez, H., Atay, I., Kaiser, M., Brun, R., Cartagena, M.M., Carballeira, N.M., Yesilada, E. and Tasdemir, D. (2011) Antiprotozoal activity of Melampyrum arvense and its metabolites. Phytotherapy research : PTR, 25 (1). pp. 142-146. 10.1002/ptr.3233.

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DOI: 10.1002/ptr.3233

Abstract

An activity guided isolation of the H(2)O subextract of the crude extract of Melampyrum arvense L. afforded iridoid glucosides: aucubin (1), melampyroside (2), mussaenoside (3), mussaenosidic acid (4), 8-epi-loganin (5); flavonoids: apigenin (6), luteolin (7), luteolin 7-O-β-glucopyranoside (8); a lignan glycoside dehydrodiconiferyl alcohol 9-O-β-glucopyranoside (9); and benzoic acid (10). β-Sitosterol (11) and a fatty acid mixture (12) were identified as the active principles of the CHCl(3) subextract. The structures of the isolates were elucidated by spectroscopic methods, while the composition of 12 was identified by GC-MS after methylation. Luteolin (7) appeared as the most active compound against Trypanosoma brucei rhodesiense and Leishmania donovani (IC(50) values 3.8 and 3.0 μg/mL). Luteolin 7-O-β-glucopyranoside (8) displayed the best antiplasmodial activity against Plasmodium falciparum (IC(50) value 2.9 μg/mL). This is the first detailed phytochemical study on Turkish M. arvense and the first report of the antiprotozoal effect of Melampyrum species and its constituents.

Item Type:Article
Uncontrolled Keywords:flavonoids; iridoid glucosides; Leishmania; Melampyrum arvense; Plasmodium; Trypanosoma
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:2954
Journal or Publication Title:Phytotherapy research : PTR
Deposited By:Library Staff
Deposited On:09 Mar 2012 16:44
Last Modified:09 Mar 2012 16:44

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