Guzman, J.D., Wube, A.A., Evangelopoulos, D., Gupta, A., Hüfner, A., Basavannacharya, C., Rahman, M.M., Thomaschitz, C., Bauer, R., McHugh, T.D., Nobeli, I., Prieto-Garcia, J.M., Gibbons, S., Bucar, F. and Bhakta, S. (2011) Interaction of N-methyl-2-alkenyl-4-quinolones with ATP-dependent MurE ligase of Mycobacterium tuberculosis: antibacterial activity, molecular docking and inhibition kinetics. Journal of Antimicrobial Chemotherapy, 66 (8). pp. 1766-1772. 10.1093/jac/dkr203.
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N-methyl-2-alkenyl-4-quinolones are inhibitors of mycobacterial and staphylococcal growth, and show MurE ligase inhibition. Therefore, they are considered as a starting point for the development of increased affinity MurE activity disruptors.
|Uncontrolled Keywords:||4-quinolones; M. tuberculosis; Mur ligase inhibitors|
|Departments, units and centres:||Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry|
|Journal or Publication Title:||Journal of Antimicrobial Chemotherapy|
|Deposited By:||Library Staff|
|Deposited On:||16 Mar 2012 11:13|
|Last Modified:||16 Mar 2012 11:13|
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