Interaction of N-methyl-2-alkenyl-4-quinolones with ATP-dependent MurE ligase of Mycobacterium tuberculosis: antibacterial activity, molecular docking and inhibition kinetics.

Guzman, J.D., Wube, A.A., Evangelopoulos, D., Gupta, A., Hüfner, A., Basavannacharya, C., Rahman, M.M., Thomaschitz, C., Bauer, R., McHugh, T.D., Nobeli, I., Prieto-Garcia, J.M., Gibbons, S., Bucar, F. and Bhakta, S. (2011) Interaction of N-methyl-2-alkenyl-4-quinolones with ATP-dependent MurE ligase of Mycobacterium tuberculosis: antibacterial activity, molecular docking and inhibition kinetics. Journal of Antimicrobial Chemotherapy, 66 (8). pp. 1766-1772. 10.1093/jac/dkr203.

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DOI: 10.1093/jac/dkr203

Abstract

N-methyl-2-alkenyl-4-quinolones are inhibitors of mycobacterial and staphylococcal growth, and show MurE ligase inhibition. Therefore, they are considered as a starting point for the development of increased affinity MurE activity disruptors.

Item Type:Article
Uncontrolled Keywords:4-quinolones; M. tuberculosis; Mur ligase inhibitors
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:2986
Journal or Publication Title:Journal of Antimicrobial Chemotherapy
Deposited By:Library Staff
Deposited On:16 Mar 2012 11:13
Last Modified:16 Mar 2012 11:13

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