Guzman, J.D., Wube, A.A., Evangelopoulos, D., Gupta, A., Hüfner, A., Basavannacharya, C., Rahman, M.M., Thomaschitz, C., Bauer, R., McHugh, T.D., Nobeli, I., Prieto-Garcia, J.M., Gibbons, S., Bucar, F. and Bhakta, S. (2011) Interaction of N-methyl-2-alkenyl-4-quinolones with ATP-dependent MurE ligase of Mycobacterium tuberculosis: antibacterial activity, molecular docking and inhibition kinetics. Journal of Antimicrobial Chemotherapy, 66 (8). pp. 1766-1772. 10.1093/jac/dkr203.
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DOI: 10.1093/jac/dkr203
Abstract
N-methyl-2-alkenyl-4-quinolones are inhibitors of mycobacterial and staphylococcal growth, and show MurE ligase inhibition. Therefore, they are considered as a starting point for the development of increased affinity MurE activity disruptors.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 4-quinolones; M. tuberculosis; Mur ligase inhibitors |
| Departments, units and centres: | Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry |
| ID Code: | 2986 |
| Journal or Publication Title: | Journal of Antimicrobial Chemotherapy |
| Deposited By: | Library Staff |
| Deposited On: | 16 Mar 2012 11:13 |
| Last Modified: | 16 Mar 2012 11:13 |
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