Tang, S., Bremner, P., Kortenkamp, A., Schlage, C., Gray, A.I., Gibbons, S. and Heinrich, M. (2003) Biflavonoids with Cytotoxic and Antibacterial Activity fromOchna macrocalyx. Planta Medica, 69 (3). pp. 247-253. 10.1055/s-2003-38478.
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Six biflavonoid and related compounds were isolated from the ethanolic extract of Ochna macrocalyx bark. One is a new compound, the isoflavanone dimer dehydroxyhexaspermone C (1). Previously isolated compounds obtained from the bark are biisoflavonoid hexaspermone C (2), tetrahydrofuran derivative ochnone (3), furobenzopyran derivative cordigol (4), and biflavonoids calodenin B (5) and dihydrocalodenin B (6). Although 3 has already been isolated, its spectral data are presented here for the first time. Isolated compounds were tested for cytotoxic activity on MCF-7 breast cancer cells using the MTF reduction assay method. Compound 5 showed cytotoxic activity (7 ± 0.5 μM) and 6 showed moderate cytotoxicity (35 ± 7 μM). In antibacterial assays performed using three strains of multi-drug resistant (mdr) Staphylococcus aureus (RN4220, XU212 and SA-1199-B) compounds 5 and in particular 6 showed strong antibacterial activity (MlCs 5:64, 8, 16 μg/mL 6:8, 8, 8 μg/mL, respectively). The ethanolic extract of the bark also showed NF-κB inhibitory activity.
|Uncontrolled Keywords:||Antibacterial; Biflavonoids; Cytotoxicity; Ethnopharm acology; mdr; NF-κB; Ochna macrocalyx; Ochnaceae|
|Departments, units and centres:||Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry|
|Journal or Publication Title:||Planta Medica|
|Deposited By:||Library Staff|
|Deposited On:||16 Mar 2012 16:45|
|Last Modified:||16 Mar 2012 16:45|
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