Biflavonoids with Cytotoxic and Antibacterial Activity fromOchna macrocalyx

Tang, S., Bremner, P., Kortenkamp, A., Schlage, C., Gray, A.I., Gibbons, S. and Heinrich, M. (2003) Biflavonoids with Cytotoxic and Antibacterial Activity fromOchna macrocalyx. Planta Medica, 69 (3). pp. 247-253. 10.1055/s-2003-38478.

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DOI: 10.1055/s-2003-38478

Abstract

Six biflavonoid and related compounds were isolated from the ethanolic extract of Ochna macrocalyx bark. One is a new compound, the isoflavanone dimer dehydroxyhexaspermone C (1). Previously isolated compounds obtained from the bark are biisoflavonoid hexaspermone C (2), tetrahydrofuran derivative ochnone (3), furobenzopyran derivative cordigol (4), and biflavonoids calodenin B (5) and dihydrocalodenin B (6). Although 3 has already been isolated, its spectral data are presented here for the first time. Isolated compounds were tested for cytotoxic activity on MCF-7 breast cancer cells using the MTF reduction assay method. Compound 5 showed cytotoxic activity (7 ± 0.5 μM) and 6 showed moderate cytotoxicity (35 ± 7 μM). In antibacterial assays performed using three strains of multi-drug resistant (mdr) Staphylococcus aureus (RN4220, XU212 and SA-1199-B) compounds 5 and in particular 6 showed strong antibacterial activity (MlCs 5:64, 8, 16 μg/mL 6:8, 8, 8 μg/mL, respectively). The ethanolic extract of the bark also showed NF-κB inhibitory activity.

Item Type:Article
Uncontrolled Keywords:Antibacterial; Biflavonoids; Cytotoxicity; Ethnopharm acology; mdr; NF-κB; Ochna macrocalyx; Ochnaceae
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:3000
Journal or Publication Title:Planta Medica
Deposited By:Library Staff
Deposited On:16 Mar 2012 16:45
Last Modified:16 Mar 2012 16:45

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