Negative interactions between phosphorylation of acetyl-CoA carboxylase by the cyclic AMP-dependent and AMP-activated protein kinases

Munday, M., Carling, D. and Hardie, D.G. (1988) Negative interactions between phosphorylation of acetyl-CoA carboxylase by the cyclic AMP-dependent and AMP-activated protein kinases. FEBS Letters, 235 (1-2). p. 144. 10.1016/0014-5793(88)81251-1.

Full text not available from this repository.

DOI: 10.1016/0014-5793(88)81251-1

Abstract

We have reported previously that cyclic AMP-dependent protein kinase phsophorylates two sites on acetyl-CoA carboxylase (site 1: Arg-Met-Ser(P)-Phe, and site 2: Ser-Per(P)-Met-Ser-Gly-Leu), while the AMP-activated protein kinase also phosphorylates site 1, plus site 3 (Ser-Ser-Met-Ser(P)-Gly-Leu), the latter being two residues C-terminal to site 2. We now report that prior phosphorylation of site 2 by cyclic AMP-dependent protein kinase prevents the subsequent phosphorylation of site 3 and the consequent large decrease in V(max) produced by the AMP-activated protein kinase. Similarly, prior phosphorylation of site 3 by the AMP-activated protein kinase prevents subsequent phosphorylation of site 2 by cyclic AMP-dependent protein kinase.

Item Type:Article
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:3025
Journal or Publication Title:FEBS Letters
Deposited By:Library Staff
Deposited On:22 Mar 2012 14:47
Last Modified:22 Mar 2012 14:47

Repository Staff Only: Item control page

School of Pharmacy Staff Only: Edit a copy to replace this item