Targeting glycolysis: a fragment based approach towards bifunctional inhibitors of hLDH-5

Moorhouse, A.D., Spiteri, C., Sharma, P., Zloh, M. and Moses, J.E. (2011) Targeting glycolysis: a fragment based approach towards bifunctional inhibitors of hLDH-5. Chemical Communications, 47 (1). pp. 230-232. 10.1039/c0cc01166e.

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DOI: 10.1039/c0cc01166e

Abstract

hLDH-5 has emerged as a promising target for anti-glycolytic cancer chemotherapy. Here we report a first generation of bifunctional inhibitors, which show promising activity against hLDH-5.

Item Type:Article
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:3043
Journal or Publication Title:Chemical Communications
Deposited By:Library Staff
Deposited On:23 Mar 2012 09:07
Last Modified:23 Mar 2012 09:07

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