Role of complexes formation between drugs and penetration enhancers in transdermal delivery

Drakulić, B.J., Juranić, I.O., Erić, S. and Zloh, M. (2008) Role of complexes formation between drugs and penetration enhancers in transdermal delivery. International Journal of Pharmaceutics, 363 (1-2). pp. 40-49. 10.1016/j.ijpharm.2008.06.032.

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DOI: 10.1016/j.ijpharm.2008.06.032

Abstract

The use of chemical penetration enhancers (CPE) is growing due to their ability to improve drug delivery through the skin. A possible mechanism of penetration enhancement could involve the complex formation between drug and components in the pharmaceutical formulation, thus altering the physicochemical properties of the active substance. Here, modelling studies indicate that hydrocarbon and oxygen-containing terpenes (penetration enhancers) could form complexes with drugs. Satisfactory correlations have been obtained between the predicted molecular properties of enhancers and their enhancement effects.

Item Type:Article
Uncontrolled Keywords:Conformational search; Penetration enhancers; Small molecule-small molecule interactions; Transdermal delivery
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:3045
Journal or Publication Title:International Journal of Pharmaceutics
Deposited By:Library Staff
Deposited On:23 Mar 2012 09:29
Last Modified:23 Mar 2012 09:29

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