Wangteeraprasert, R., Lipipun, V., Gunaratnam, M., Neidle, S., Gibbons, S. and Likhitwitayawuid, K. (2012) Bioactive Compounds from Carissa spinarum. Phytotherapy Research . 10.1002/ptr.4607.
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In our continuing efforts to find new antiherpetic agents from plants, an extract prepared from the stems of Carissa spinarum L. was found to possess appreciable activity against herpes simplex viruses (HSV I and II). A chemical study of this plant was then initiated, and this led to the isolation of 12 compounds, including a coumarin, two cardiac glycosides and nine lignans. These isolated compounds were evaluated for several biological activities, including antiherpetic, cytotoxic, antioxidant and antibacterial effects. The cardiac glycoside evomonoside was found to be the only antiherpetic principle, showing moderate activity against herpes simplex virus types I and II in the inactivation method. The lignans (-)-carinol, (-)-carissanol and (-)-nortrachelogenin exhibited cytotoxicity against breast (MCF7) and lung (A549) cancer cells. Moderate anti-DPPH free radical activity was observed for all the lignans. None of the isolates showed antibacterial activity.
|Uncontrolled Keywords:||Antioxidant; Cardiac glycoside; Carissa; Cytotoxic; Herpes simplex; Lignan|
|Departments, units and centres:||Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry|
|Journal or Publication Title:||Phytotherapy Research|
|Deposited By:||Library Staff|
|Deposited On:||23 Mar 2012 11:34|
|Last Modified:||23 Mar 2012 11:34|
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