Das, S., Yasmin, H., Mehedi Masud, M., Roy, S.C., Nahar, L., Mukhlesur Rahman, M., Gibbons, S., Bachar, S.C. and Sarker, S.D. (2008) Total synthesis and analgesic activity of 6-fluoroindan-1-carboxylic acid. Tetrahedron, 64 (37). pp. 8642-8646. 10.1016/j.tet.2008.07.010.
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6-Fluoroindan-1-carboxylic acid (4) was conveniently synthesised from 3-fluorobenzaldehyde in six steps. The structure of this new compound and three other intermediates, 3-fluorophenylcyanoethylacrylate (1), 3-fluorophenyl succinic acid (2) and 6-fluoro-3-oxo-indan-1-carboxylic acid (3) was elucidated by comprehensive spectral data analyses. The analgesic activity of compounds 3 and 4 was assessed by the acetic acid induced writhing in Swiss albino mice.
|Uncontrolled Keywords:||3-Fluorophenyl succinic acid; 3-Fluorophenylcyanoethylacrylate; 6-Fluoro-3-oxo-indan-1-carboxylic acid; 6-Fluoroindan-1-carboxylic acid; Analgesic activity|
|Departments, units and centres:||Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry|
|Journal or Publication Title:||Tetrahedron|
|Deposited By:||Library Staff|
|Deposited On:||23 Mar 2012 16:43|
|Last Modified:||23 Mar 2012 16:43|
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