Smyrniotopoulos, V., Vagias, C., Rahman, M.M., Gibbons, S. and Roussis, V. (2008) Brominated Diterpenes with Antibacterial Activity from the Red AlgaSphaerococcus coronopifolius. Journal of Natural Products, 71 (8). pp. 1386-1392. 10.1021/np8001817.
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Four new brominated diterpenes (1, 2, 4, 5), along with two previously reported metabolites (3, 6), were isolated from the organic extract of Sphaerococcus coronopifolius, collected in Palaiokastritsa Bay at the west coast of Corfu Island. The structures of the new products, as well as their relative configuration, were established by means of spectroscopic data analyses, including 2D NMR experiments. The isolated metabolites were evaluated for their antibacterial activity against a panel of multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA) with MICs in the range 0.5-128 μg/mL.
|Departments, units and centres:||Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry|
|Journal or Publication Title:||Journal of Natural Products|
|Deposited By:||Library Staff|
|Deposited On:||23 Mar 2012 17:40|
|Last Modified:||23 Mar 2012 17:40|
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