Guaianolide sesquiterpenes from Pulicaria crispa (Forssk.) Oliv.

Stavri, M., Mathew, K.T., Gordon, A., Shnyder, S.D., Falconer, R.A. and Gibbons, S. (2008) Guaianolide sesquiterpenes from Pulicaria crispa (Forssk.) Oliv. Phytochemistry, 69 (9). pp. 1915-1918. 10.1016/j.phytochem.2008.03.012.

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DOI: 10.1016/j.phytochem.2008.03.012

Abstract

A phytochemical study of the asteraceous herb Pulicaria crispa (Forssk.) Oliv. resulted in the characterisation of three guaianolide sesquiterpenes, 2α,4α-dihydroxy-7αH,8αH,10αH-guaia-1(5),11(13)-dien-8β,12-olide (1), 1α,2α-epoxy-4β-hydroxy-5αH,7αH,8αH,10αH-guaia-11(13)-en-8β,12-olide (2) and 5,10-epi-2,3-dihydroaromatin (3). The structures were assigned on the basis of extensive 1 and 2D NMR experiments. Compound 3 exhibited weak antimycobacterial activity against Mycobacterium phlei with a minimum inhibitory concentration of 0.52 mM and cytotoxicity (IC50 of 5.8 ± 0.2 μM) in a human bladder carcinoma cell line, EJ-138.

Item Type:Article
Uncontrolled Keywords:Guaianolide; Mycobacterium; Pseudoguaianolide; Pulicaria crispa; Sesquiterpene
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:3075
Journal or Publication Title:Phytochemistry
Deposited By:Library Staff
Deposited On:23 Mar 2012 17:46
Last Modified:23 Mar 2012 17:46

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