Stavri, M., Mathew, K.T., Gordon, A., Shnyder, S.D., Falconer, R.A. and Gibbons, S. (2008) Guaianolide sesquiterpenes from Pulicaria crispa (Forssk.) Oliv. Phytochemistry, 69 (9). pp. 1915-1918. 10.1016/j.phytochem.2008.03.012.
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A phytochemical study of the asteraceous herb Pulicaria crispa (Forssk.) Oliv. resulted in the characterisation of three guaianolide sesquiterpenes, 2α,4α-dihydroxy-7αH,8αH,10αH-guaia-1(5),11(13)-dien-8β,12-olide (1), 1α,2α-epoxy-4β-hydroxy-5αH,7αH,8αH,10αH-guaia-11(13)-en-8β,12-olide (2) and 5,10-epi-2,3-dihydroaromatin (3). The structures were assigned on the basis of extensive 1 and 2D NMR experiments. Compound 3 exhibited weak antimycobacterial activity against Mycobacterium phlei with a minimum inhibitory concentration of 0.52 mM and cytotoxicity (IC50 of 5.8 ± 0.2 μM) in a human bladder carcinoma cell line, EJ-138.
|Uncontrolled Keywords:||Guaianolide; Mycobacterium; Pseudoguaianolide; Pulicaria crispa; Sesquiterpene|
|Departments, units and centres:||Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry|
|Journal or Publication Title:||Phytochemistry|
|Deposited By:||Library Staff|
|Deposited On:||23 Mar 2012 17:46|
|Last Modified:||23 Mar 2012 17:46|
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