The lower-generation polypropylenimine dendrimers are effective gene-transfer agents.

Zinselmeyer, B.H., Mackay, S.P., Schatzlein, A.G. and Uchegbu, I.F. (2002) The lower-generation polypropylenimine dendrimers are effective gene-transfer agents. Pharmaceutical research, 19 (7). pp. 960-967.

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Abstract

The generation 2 polypropylenimine dendrimer combines a sufficient level of DNA binding with a low level of cell cytoxicity to give it optimum in vitro gene transfer activity.

Item Type:Article
Uncontrolled Keywords:cultureddnadna administration & dosagedna geneticsdrug delivery systemsdrug delivery systems methodsescherichia coligene transfer techniqueshumansiminesimines administration & dosageimines chemistryimines toxicitymodelsmolecularpolypropylenespolypropylenes administration & dosagepolypropylenes chemistrypolypropylenes toxicitytumor cells
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:3086
Journal or Publication Title:Pharmaceutical research
Deposited By:Library Staff
Deposited On:20 Apr 2012 14:54
Last Modified:20 Apr 2012 14:58

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