The Effect of Monomers and of Micellar and Vesicular Forms of Non-ionic Surfactants (Solulan C24 and Solulan 16) on Caco-2 Cell Monolayers

Dimitrijevic, D., Lamandin, C., Uchegbu, I.F., Shaw, A.J. and Florence, A.T. (2011) The Effect of Monomers and of Micellar and Vesicular Forms of Non-ionic Surfactants (Solulan C24 and Solulan 16) on Caco-2 Cell Monolayers. Journal of Pharmacy and Pharmacology, 49 (6). pp. 611-616. 10.1111/j.2042-7158.1997.tb06854.x.

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DOI: 10.1111/j.2042-7158.1997.tb06854.x

Abstract

Measurements of transepithelial electrical resistance (TEER), the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) test and monitoring of poly(ethylene glycol) (PEG) transport have been used to study the effects of the non-ionic surfactants Solulan C24 and Solulan 16, either free in solution or as an integral part of niosome bi-layers, on intestinal epithelial cells from man (Caco-2 cell monolayers). The effects on epithelial integrity and on the transport of the hydrophilic drug metformin depend on the concentration of the surfactants. At concentrations above 1% the effect on TEER of the surfactant in niosomal form and free in solution were equivalent whereas cell viability was preserved to a higher concentration of Solulans when the Solulans were present in the niosomal form. It was concluded that the toxic effect of niosomes arises from free surfactant present in the niosome suspension.

Item Type:Article
Departments, units and centres:Department of Pharmaceutics > Department of Pharmaceutics
ID Code:3104
Journal or Publication Title:Journal of Pharmacy and Pharmacology
Deposited By:Library Staff
Deposited On:26 Apr 2012 11:51
Last Modified:26 Apr 2012 11:51

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