Reboxetine modulates norepinephrine efflux in the frontal cortex of the freely moving rat: the involvement of α2 and 5-HT1A receptors

Owen, J.C.E. and Whitton, P.S. (2003) Reboxetine modulates norepinephrine efflux in the frontal cortex of the freely moving rat: the involvement of α2 and 5-HT1A receptors. Neuroscience Letters, 348 (3). pp. 171-174. 10.1016/S0304-3940(03)00792-4.

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DOI: 10.1016/S0304-3940(03)00792-4

Abstract

The effect of reboxetine on norepinephrine (NE) efflux in the frontalcortex of freelymovingrats has been studied using in vivo microdialysis. Reboxetine was administered either by injection (10 and 30 mg/kg i.p.) or directly to the frontalcortex via the dialysis probe (10 and 100 μM). To further elucidate the mechanism of action of reboxetine in this region yohimbine (10 μM) was co-infused with reboxetine via the frontalcortex probe. Both routes of administration of reboxetine resulted in a drug-induced, dose-dependent decrease in frontalcortex NE efflux. This effect was reversed following co-infusion of yohimbine, which has been shown to possess both α2-adrenoceptor antagonist and 5-HT1A agonist properties.

Item Type:Article
Uncontrolled Keywords:Norepinephrine; In vivo microdialysis; Frontalcortex; Reboxetine; Yohimbine; WAY 100 635
Departments, units and centres:Department of Pharmacology > Department of Pharmacology
ID Code:3119
Journal or Publication Title:Neuroscience Letters
Deposited By:Library Staff
Deposited On:27 Apr 2012 12:53
Last Modified:27 Apr 2012 12:53

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