Reboxetine modulates norepinephrine efflux in the frontal cortex of the freely moving rat: the involvement of α2 and 5-HT1A receptors

Abstract

The effect of reboxetine on norepinephrine (NE) efflux in the frontalcortex of freelymovingrats has been studied using in vivo microdialysis. Reboxetine was administered either by injection (10 and 30 mg/kg i.p.) or directly to the frontalcortex via the dialysis probe (10 and 100 μM). To further elucidate the mechanism of action of reboxetine in this region yohimbine (10 μM) was co-infused with reboxetine via the frontalcortex probe. Both routes of administration of reboxetine resulted in a drug-induced, dose-dependent decrease in frontalcortex NE efflux. This effect was reversed following co-infusion of yohimbine, which has been shown to possess both α2-adrenoceptor antagonist and 5-HT1A agonist properties.