Owen, J.C.E. and Whitton, P.S. (2003) Reboxetine modulates norepinephrine efflux in the frontal cortex of the freely moving rat: the involvement of α2 and 5-HT1A receptors. Neuroscience Letters, 348 (3). pp. 171-174. 10.1016/S0304-3940(03)00792-4.
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The effect of reboxetine on norepinephrine (NE) efflux in the frontalcortex of freelymovingrats has been studied using in vivo microdialysis. Reboxetine was administered either by injection (10 and 30 mg/kg i.p.) or directly to the frontalcortex via the dialysis probe (10 and 100 μM). To further elucidate the mechanism of action of reboxetine in this region yohimbine (10 μM) was co-infused with reboxetine via the frontalcortex probe. Both routes of administration of reboxetine resulted in a drug-induced, dose-dependent decrease in frontalcortex NE efflux. This effect was reversed following co-infusion of yohimbine, which has been shown to possess both α2-adrenoceptor antagonist and 5-HT1A agonist properties.
|Uncontrolled Keywords:||Norepinephrine; In vivo microdialysis; Frontalcortex; Reboxetine; Yohimbine; WAY 100 635|
|Departments, units and centres:||Department of Pharmacology > Department of Pharmacology|
|Journal or Publication Title:||Neuroscience Letters|
|Deposited By:||Library Staff|
|Deposited On:||27 Apr 2012 12:53|
|Last Modified:||27 Apr 2012 12:53|
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