Effect of tetanus toxin on basal and evoked release of 5-hydroxytryptamine and dopamine in rat hippocampus in vivo

Britton, P., Whitton, P.S. and Bowery, N.G. (1995) Effect of tetanus toxin on basal and evoked release of 5-hydroxytryptamine and dopamine in rat hippocampus in vivo. Brain Research, 673 (2). pp. 331-334. 10.1016/0006-8993(94)01458-T.

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DOI: 10.1016/0006-8993(94)01458-T

Abstract

Tetanus toxin is a potent neurotoxin which produces seizures and usually death in mammals. In the present study, we have investigated the effect of tetanus toxin on extracellular basal and evoked release of 5-hydroxytryptamine (5-HT), dopamine (DA) and their metabolites in vivo, 7 days after toxin injection into the hippocampus of rats. Tetanus toxin decreased both basal and evoked release of 5-HT and DA. The 5-HT metabolite 5-hydroxyindoleacetic acid (5-HIAA) was not significantly decreased in the extracellular space. Of the DA metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) concentration was decreased while that of homoillic acid (HVA) was unchanged. These findings are considered in light of the possible contributory role that a decrease in monoamine concentration in the hippocampus might have in the effects of tetanus toxin.

Item Type:Article
Uncontrolled Keywords:Tetanus toxin; 5-HT; DA; Microdialysis
Departments, units and centres:Department of Pharmacology > Department of Pharmacology
ID Code:3134
Journal or Publication Title:Brain Research
Deposited By:Library Staff
Deposited On:03 May 2012 11:06
Last Modified:03 May 2012 11:06

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