Britton, P., Whitton, P.S. and Bowery, N.G. (1995) Effect of tetanus toxin on basal and evoked release of 5-hydroxytryptamine and dopamine in rat hippocampus in vivo. Brain Research, 673 (2). pp. 331-334. 10.1016/0006-8993(94)01458-T.
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DOI: 10.1016/0006-8993(94)01458-T
Abstract
Tetanus toxin is a potent neurotoxin which produces seizures and usually death in mammals. In the present study, we have investigated the effect of tetanus toxin on extracellular basal and evoked release of 5-hydroxytryptamine (5-HT), dopamine (DA) and their metabolites in vivo, 7 days after toxin injection into the hippocampus of rats. Tetanus toxin decreased both basal and evoked release of 5-HT and DA. The 5-HT metabolite 5-hydroxyindoleacetic acid (5-HIAA) was not significantly decreased in the extracellular space. Of the DA metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) concentration was decreased while that of homoillic acid (HVA) was unchanged. These findings are considered in light of the possible contributory role that a decrease in monoamine concentration in the hippocampus might have in the effects of tetanus toxin.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Tetanus toxin; 5-HT; DA; Microdialysis |
| Departments, units and centres: | Department of Pharmacology > Department of Pharmacology |
| ID Code: | 3134 |
| Journal or Publication Title: | Brain Research |
| Deposited By: | Library Staff |
| Deposited On: | 03 May 2012 11:06 |
| Last Modified: | 03 May 2012 11:06 |
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