N-methyl-d-aspartate receptors modulate extracellular dopamine concentration and metabolism in rat hippocampus and striatum in vivo

Whitton, P.S., Maione, S., Biggs, C.S. and Fowler, L.J. (1994) N-methyl-d-aspartate receptors modulate extracellular dopamine concentration and metabolism in rat hippocampus and striatum in vivo. Brain Research, 635 (1-2). pp. 312-316. 10.1016/0006-8993(94)91453-2.

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DOI: 10.1016/0006-8993(94)91453-2

Abstract

The effects of infusingN-methyl-d-aspartate (NMDA), and the specific NMDA receptor antagonistd-2-amino-5-phosphonoproprionic acid (d-AP5) into rat hippocampus and stiatum on extracellular dopamine (DA) and its metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were studied using intracerebral microdialysis. In striatum NMDA increased DA extracellularly in a concentration-dependent manner. Against a 10 μM concentration of NMDA the increase in striatal DA was opposed byD-AP5 (10 μM in all experiments), which when infused alone significanlty reduced DA concentration. Infusion of NMDA and DOPAC level in a complex manner, with 10 μM concentration causing a significant increase 2 h after infusion, while 100 μM NMDA caused a transcient decrease in the metabolite. None of the treatments altered striatal dialysate HVA. In hippocampus NMDA infusion decreased dialysate DA concentration-dependent manner, and the decrease caused by 10 μM NMDA was reversed byD-AP5. When given alone the antagonist was without effect. NMDA infusion elevated hippocampal dialysate DOPAC and HVA, while HVA was decreased followingD-AP5 infusion. These data indicate that DA release is reginally controlled by excitatory amino acids, but in differential manner.

Item Type:Article
Uncontrolled Keywords:NDMA; Dopamine; DOPAC; HVA; Intracerebral dialysis
Departments, units and centres:Department of Pharmacology > Department of Pharmacology
ID Code:3139
Journal or Publication Title:Brain Research
Deposited By:Library Staff
Deposited On:03 May 2012 11:28
Last Modified:03 May 2012 11:28

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