The effect of valproic acid on 5-hydroxytiyptamine and 5-hydroxyindoleacetic acid concentration in hippocampal dialysates In vivo

Whitton, P.S. and Fowler, L.J. (1991) The effect of valproic acid on 5-hydroxytiyptamine and 5-hydroxyindoleacetic acid concentration in hippocampal dialysates In vivo. European Journal of Pharmacology, 200 (1). pp. 167-169. 10.1016/0014-2999(91)90681-F.

Full text not available from this repository.

DOI: 10.1016/0014-2999(91)90681-F

Abstract

The effect of valproic acid (100, 200 and 400 mg/kg i.p.) on extracellular 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) has been studied using intracerebral microdialysis of the ventral hippocampus. Valproate caused a dose-dependent increase in didlysate 5-HT, but in contrast no effect on 5-HIAA level was observed. These findings are considered with regard to a possible role of 5-HT in mediating the anticonvulsant action of valproate.

Item Type:Article
Uncontrolled Keywords:Valproate; 5-HT (5-hyddroxytryptamine, serotonin); Microdialysis
Departments, units and centres:Department of Pharmacology > Department of Pharmacology
ID Code:3143
Journal or Publication Title:European Journal of Pharmacology
Deposited By:Library Staff
Deposited On:03 May 2012 11:41
Last Modified:03 May 2012 11:41

Repository Staff Only: Item control page

School of Pharmacy Staff Only: Edit a copy to replace this item