Whitton, P.S. and Fowler, L.J. (1991) The effect of valproic acid on 5-hydroxytiyptamine and 5-hydroxyindoleacetic acid concentration in hippocampal dialysates In vivo. European Journal of Pharmacology, 200 (1). pp. 167-169. 10.1016/0014-2999(91)90681-F.
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DOI: 10.1016/0014-2999(91)90681-F
Abstract
The effect of valproic acid (100, 200 and 400 mg/kg i.p.) on extracellular 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) has been studied using intracerebral microdialysis of the ventral hippocampus. Valproate caused a dose-dependent increase in didlysate 5-HT, but in contrast no effect on 5-HIAA level was observed. These findings are considered with regard to a possible role of 5-HT in mediating the anticonvulsant action of valproate.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Valproate; 5-HT (5-hyddroxytryptamine, serotonin); Microdialysis |
| Departments, units and centres: | Department of Pharmacology > Department of Pharmacology |
| ID Code: | 3143 |
| Journal or Publication Title: | European Journal of Pharmacology |
| Deposited By: | Library Staff |
| Deposited On: | 03 May 2012 11:41 |
| Last Modified: | 03 May 2012 11:41 |
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