Whitton, P.S. and Fowler, L.J. (1991) The effect of valproic acid on 5-hydroxytiyptamine and 5-hydroxyindoleacetic acid concentration in hippocampal dialysates In vivo. European Journal of Pharmacology, 200 (1). pp. 167-169. 10.1016/0014-2999(91)90681-F.
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The effect of valproic acid (100, 200 and 400 mg/kg i.p.) on extracellular 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) has been studied using intracerebral microdialysis of the ventral hippocampus. Valproate caused a dose-dependent increase in didlysate 5-HT, but in contrast no effect on 5-HIAA level was observed. These findings are considered with regard to a possible role of 5-HT in mediating the anticonvulsant action of valproate.
|Uncontrolled Keywords:||Valproate; 5-HT (5-hyddroxytryptamine, serotonin); Microdialysis|
|Departments, units and centres:||Department of Pharmacology > Department of Pharmacology|
|Journal or Publication Title:||European Journal of Pharmacology|
|Deposited By:||Library Staff|
|Deposited On:||03 May 2012 11:41|
|Last Modified:||03 May 2012 11:41|
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