Effects of tianeptine on stress-induced behavioural deficits and 5-HT dependent behaviour

Whitton, P. S., Sarna, G. S., Datla, K. P. and Curzon, G. (1991) Effects of tianeptine on stress-induced behavioural deficits and 5-HT dependent behaviour. Psychopharmacology, 104 (1). pp. 81-85. 10.1007/BF02244558.

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DOI: 10.1007/BF02244558


The novel tricyclic antidepressant drug tianeptine had an antidepressant-like effect on a rat model of depression based on the deficit in open field activity observed on the day after 2 h restraint. Thus, when tianeptine (10 mg/kg IP) was given 2 h after the end of the restraint to either untreated rats or to animals previously given 10 mg/kg of the drug per day for 13 days, then the deficit was opposed. Tianeptine, given acutely but not chronically, moderately enhanced the 5-HT1C receptor-dependent hypolocomotor effect ofm-chlorophenylpiperazine (mCPP) but did not alter other 5-HT1 receptor subtype-dependent behaviour. Acute but not chronic tianeptine also decreased 5-HT2 receptor-dependent body shakes induced by 5-hydroxytryptophan. Shakes induced by the 5-HT2 agonist 1-(2,5-dimethoxy-4-iodophenyl)-2 aminopropane (DOI) were unaffected. The results are discussed in relation to the possible mechanism of antidepressant action of tianeptine.

Item Type:Article
Uncontrolled Keywords:Antidepressant drugs - Depression - 5-HT2 receptor - Tianeptine
Departments, units and centres:Department of Pharmacology > Department of Pharmacology
ID Code:3144
Journal or Publication Title:Psychopharmacology
Deposited By:Library Staff
Deposited On:03 May 2012 11:45
Last Modified:03 May 2012 11:45

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