Polypeptides and polyaminoacids in drug delivery

González-Aramundiz, J.V., Lozano, M.V., Sousa-Herves, A., Fernandez-Megia, E. and Csaba, N. (2012) Polypeptides and polyaminoacids in drug delivery. Expert Opinion on Drug Delivery, 9 (2). pp. 183-201. 10.1517/17425247.2012.647906.

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DOI: 10.1517/17425247.2012.647906

Abstract

Introduction: Advances achieved over the last few years in drug delivery have provided novel and versatile possibilities for the treatment of various diseases. Among the biomaterials applied in this field, it is worth highlighting the increasing importance of polyaminoacids and polypeptides. The appealing properties of these polymers are very promising for the design of novel compositions in a variety of drug delivery applications. Areas covered: This review provides an overview on the general characteristics of polyaminoacids and polypeptides and briefly discusses different synthetic pathways for their production. This is followed by a detailed description of different drug delivery applications of these polymers, emphasizing those examples that already reached advanced preclinical development or have entered clinical trials. Expert opinion: Polyaminoacids and polypeptides are gaining much attention in drug delivery due to their exceptional properties. Their application as polymers for drug delivery purposes has been sped up by the significant achievements related to their synthesis. Certainly, cancer therapy has benefited the most from these advances, although other fields such as vaccine delivery and alternative administration routes are also being successfully explored. The design of new entities based on polyaminoacids and polypeptides and the improved insight gained in drug delivery guarantee exciting findings in the near future.

Item Type:Article
Uncontrolled Keywords:cancer therapy, drug delivery systems, gene delivery, nanomedicine, polyaminoacid, polypeptide
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:3175
Journal or Publication Title:Expert Opinion on Drug Delivery
Deposited By:Library Staff
Deposited On:04 May 2012 16:02
Last Modified:04 May 2012 16:02

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