Anti-adhesive glycoproteins in echinoderm mucus secretions

Bavington, C.D., Lever, R., Mulloy, B., Grundy, M.M., Page, C.P., Richardson, N.V. and McKenzie, J.D. (2004) Anti-adhesive glycoproteins in echinoderm mucus secretions. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 139 (4). pp. 607-617. 10.1016/j.cbpc.2004.07.008.

Full text not available from this repository.

DOI: 10.1016/j.cbpc.2004.07.008


Marine invertebrates produce a large variety of mucussecretions which are rich in glycoproteins. As part of our studies of natural antifouling mechanisms, mucussecretions from the starfish Marthasterias glacialis and Porania pulvillus and the brittlestar Ophiocomina nigra have been used to characterise the structure and function of some of the glycoproteins present in these secretions. Mucus was collected from all three species and fractionated by size exclusion chromatography. A high molecular weight glycoprotein fraction was collected from each species. Monosaccharide analysis and FTIR demonstrated a composition consistent with a mucin-type glycoprotein. The mucin from M. glacialis and O. nigra inhibited in vitro bacterial adhesion in a dose-dependent manner. In contrast, the mucin from P. pulvillus promoted bacterial adhesion in a dose-dependent manner. All of the mucins inhibited the adhesion of human neutrophils to cultured human vascular endothelial cells (HUVECs) and had no anticoagulant activity. The mucins described here have adhesion-regulating functions that may have a role in the antifouling or feeding mechanisms of the organisms that produce them. These mucins may also be of therapeutic value through their ability to regulate human neutrophil adhesion or bacterial adhesion.

Item Type:Article
Uncontrolled Keywords:adhesion; biofouling; echinoderm; glycoprotein; leukocyte; mucin; Mucus; pseudomonas
Departments, units and centres:Department of Pharmacology > Department of Pharmacology
ID Code:3187
Journal or Publication Title:Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology
Deposited By:Library Staff
Deposited On:10 May 2012 14:19
Last Modified:10 May 2012 14:19


Item downloaded times since 10 May 2012 14:19.

View statistics for "Anti-adhesive glycoproteins in echinoderm mucus secretions"

Repository Staff Only: Item control page

School of Pharmacy Staff Only: Edit a copy to replace this item