Role of glycosaminoglycans in inflammation

Lever, R., Smailbegovic, A. and Page, C.P. (2001) Role of glycosaminoglycans in inflammation. InflammoPharmacology, 9 (1-2). pp. 165-169. 10.1163/156856001300248443.

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DOI: 10.1163/156856001300248443


Glycosaminoglycans (GAGs) are large, polyanionic molecules expressed throughout the body, either in association with cell surfaces and extracellular matrices, or stored within intracellular compartments. The GAG heparin is synthesised by and stored exclusively in mast cells, which are strongly associated with allergy and inflammation and is co-released with histamine upon cellular degranulation. The closely related GAG heparan sulphate is expressed, as part of a proteoglycan, on cell surfaces. Most notably, heparan sulphate is associated with the surfaces of vascular endothelial cells, known to be pivotally involved in the control of inflammatory cell adhesion and extravasation. The physiological role of these molecules is not well understood but evidence suggests that they may be involved in limitation of the inflammatory response and, in particular, regulation of cell adhesion and trafficking.

Item Type:Article
Departments, units and centres:Department of Pharmacology > Department of Pharmacology
ID Code:3194
Journal or Publication Title:InflammoPharmacology
Deposited By:Library Staff
Deposited On:10 May 2012 15:51
Last Modified:10 May 2012 15:51


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