Starcevic, A., Jaspars, M., Cullum, J., Hranueli, D. and Long, P.F. (2007) Predicting the Nature and Timing of Epimerisation on a Modular Polyketide Synthase. ChemBioChem, 8 (1). pp. 28-31. 10.1002/cbic.200600399.
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When and where? Modular polyketide synthases catalyse the Claisen condensation of simple organic acids with inversion of configuration to give a 2R methyl centre. However, according to Celmer's rules, the ultimate stereochemical configuration of many polyketides requires epimerisation to the 2S isomer. It has been generally believed that the epimerisation is performed by the ketosynthase domains. We challenge this traditional thinking and propose bifunctionality of the ketoreductase domains.
|Departments, units and centres:||Department of Pharmaceutics > Department of Pharmaceutics|
|Journal or Publication Title:||ChemBioChem|
|Deposited By:||Library Staff|
|Deposited On:||11 May 2012 11:39|
|Last Modified:||11 May 2012 11:39|
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