Predicting the Nature and Timing of Epimerisation on a Modular Polyketide Synthase

Starcevic, A., Jaspars, M., Cullum, J., Hranueli, D. and Long, P.F. (2007) Predicting the Nature and Timing of Epimerisation on a Modular Polyketide Synthase. ChemBioChem, 8 (1). pp. 28-31. 10.1002/cbic.200600399.

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DOI: 10.1002/cbic.200600399

Abstract

When and where? Modular polyketide synthases catalyse the Claisen condensation of simple organic acids with inversion of configuration to give a 2R methyl centre. However, according to Celmer's rules, the ultimate stereochemical configuration of many polyketides requires epimerisation to the 2S isomer. It has been generally believed that the epimerisation is performed by the ketosynthase domains. We challenge this traditional thinking and propose bifunctionality of the ketoreductase domains.

Item Type:Article
Uncontrolled Keywords:enzymes;epimerization;erythromycin;polyketides;stereochemistry
Departments, units and centres:Department of Pharmaceutics > Department of Pharmaceutics
ID Code:3207
Journal or Publication Title:ChemBioChem
Deposited By:Library Staff
Deposited On:11 May 2012 11:39
Last Modified:11 May 2012 11:39

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