Genetics of Streptomyces rimosus, the oxytetracycline producer.

Petković, H., Cullum, J., Hranueli, D., Hunter, I.S., Perić-Concha, N., Pigac, J., Thamchaipenet, A., Vujaklija, D. and Long, P.F. (2006) Genetics of Streptomyces rimosus, the oxytetracycline producer. Microbiology and molecular biology reviews: MMBR, 70 (3). pp. 704-728. 10.1128/MMBR.00004-06.

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DOI: 10.1128/MMBR.00004-06

Abstract

From a genetic standpoint, Streptomyces rimosus is arguably the best-characterized industrial streptomycete as the producer of oxytetracycline and other tetracycline antibiotics. Although resistance to these antibiotics has reduced their clinical use in recent years, tetracyclines have an increasing role in the treatment of emerging infections and noninfective diseases. Procedures for in vivo and in vitro genetic manipulations in S. rimosus have been developed since the 1950s and applied to study the genetic instability of S. rimosus strains and for the molecular cloning and characterization of genes involved in oxytetracycline biosynthesis. Recent advances in the methodology of genome sequencing bring the realistic prospect of obtaining the genome sequence of S. rimosus in the near term.

Item Type:Article
Departments, units and centres:Department of Pharmaceutics > Department of Pharmaceutics
ID Code:3208
Journal or Publication Title:Microbiology and molecular biology reviews: MMBR
Deposited By:Library Staff
Deposited On:11 May 2012 11:49
Last Modified:11 May 2012 11:49

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