Long, P.F., Dunlap, W.C., Battershill, C,.N. and Jaspars, M. (2005) Shotgun Cloning and Heterologous Expression of the Patellamide Gene Cluster as a Strategy to Achieving Sustained Metabolite Production. ChemBioChem, 6 (10). pp. 1760-1765. 10.1002/cbic.200500210.
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Abstract
Shotgun cloning into E. coli of genomic DNA from Prochloron sp., symbiont of the seasquirt Lissoclinum patella, resulted in the heterologous expression of the patellamide gene cluster and subsequent production of patellamide D (1) and ascidiacyclamide (2) at levels of 80–100 ng mL−1.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | peptides;Escherichia coli;heterologous expression;HPLC-MS;natural products;patellamides |
| Departments, units and centres: | Department of Pharmaceutics > Department of Pharmaceutics |
| ID Code: | 3215 |
| Journal or Publication Title: | ChemBioChem |
| Deposited By: | Library Staff |
| Deposited On: | 11 May 2012 17:24 |
| Last Modified: | 11 May 2012 17:24 |
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