Mining the microbial metabolome: a new frontier for natural product lead discovery

Peric-Concha, N. and Long, P.F. (2003) Mining the microbial metabolome: a new frontier for natural product lead discovery. Drug Discovery Today, 8 (23). pp. 1078-1084. 10.1016/S1359-6446(03)02901-5.

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DOI: 10.1016/S1359-6446(03)02901-5

Abstract

Traditionally, natural products have been important sources of new leads for the pharmaceutical industry [1], but with discovery rates of novel structural classes in decline [2], the need to bioprospect alternate sources of chemical diversity is evident. Microbial genome sequencing projects have revealed the presence of 'silent' biosynthetic gene clusters where there is no current detectable product [3]. Likewise, culture-independent techniques have provided access to the collective genomes of environmental microflora [4]. Both sources of molecular diversity could encode potentially valuable metabolites. The ability to measure the entire complement of metabolites within microorganisms that are used as surrogate hosts to express such gene clusters will be crucial to the exploitation of these yet untapped reservoirs of metabolic diversity for future natural product drug discovery.

Item Type:Article
Uncontrolled Keywords:Streptomyces; polyketides; metabolomics; metagenome
Departments, units and centres:Department of Pharmaceutics > Department of Pharmaceutics
ID Code:3220
Journal or Publication Title:Drug Discovery Today
Deposited By:Library Staff
Deposited On:11 May 2012 17:57
Last Modified:11 May 2012 17:57

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