Potential applications of microcalorimetry for the study of physical processes in pharmaceuticals

Gaisford, S. and Buckton, G. (2001) Potential applications of microcalorimetry for the study of physical processes in pharmaceuticals. Thermochimica Acta, 380 (2). pp. 185-198. 10.1016/S0040-6031(01)00669-4.

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DOI: 10.1016/S0040-6031(01)00669-4

Abstract

In calorimetry, the heat-flow to or from a sample is measured as a function of time (isothermal calorimetry) or temperature (scanning calorimetry). The technique is not dependent on the physical form of the sample and is usually non-destructive (exceptions include temperature-induced irreversible phase transitions and thermal decomposition). The inherent sensitivity of modern instruments allows measurements on the micro-Watt scale. Calorimetry is highly suited to the study of pharmaceutical systems because small sample masses are usually required and the technique is very sensitive to changes induced by, for instance, formulation or processing. It is the purpose of this review to show applications of both isothermal and scanning calorimetry in the field of physical and bio-physical pharmacy. Potential applications include studies of physical stability, excipient compatibility, chemical stability and the study of the potential interactions of and between macromolecules such as lipids, surfactants, and nucleic acids.

Item Type:Article
Uncontrolled Keywords:Isothermal microcalorimetry; High-sensitivity differential scanning calorimetry; Titration calorimetry; Excipient compatibility; Drug stability
Departments, units and centres:Department of Pharmaceutics > Department of Pharmaceutics
ID Code:3234
Journal or Publication Title:Thermochimica Acta
Deposited By:Library Staff
Deposited On:17 May 2012 15:52
Last Modified:17 May 2012 15:52

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