An exploration of inter-relationships between contact angle, inverse phase gas chromatography and triboelectric charging data

Ahfat, N.M., Buckton, G., Burrows, R. and Ticehurst, M.D. (2000) An exploration of inter-relationships between contact angle, inverse phase gas chromatography and triboelectric charging data. European Journal of Pharmaceutical Sciences, 9 (3). pp. 271-276. 10.1016/S0928-0987(99)00063-9.

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DOI: 10.1016/S0928-0987(99)00063-9

Abstract

Surfaces of pharmaceutical powders have been assessed using contact angle, inverse phase gas chromatography (IGC) and triboelectric (electrostatic) charging techniques. The suitability of the Dynamic Angle Tester (DAT), an instrument based on the sessile drop technique, in determining contact angles and then the surface energy of pharmaceutical powders was assessed. The dispersive components of the surface energy of powders determined from the DAT and IGC method ranked the powders in the same order. The dispersive component values obtained by IGC were, as expected, higher than those from the DAT, due to IGC probing the highest energy sites on the powder surface. IGC and triboelectric studies allow materials to be characterised in terms of their electron donating–accepting tendencies, so inter-relationships between the data from the two techniques were explored. Although the data set was limited, there appeared to be a correlation between the charges developed by the powders on contact with stainless steel and the ratio of the electron-donating to electron-accepting tendencies of the materials as obtained from IGC.

Item Type:Article
Uncontrolled Keywords:Contact angle; Surface energy; Inverse gas chromatography; Triboelectric; Electrostatic charging
Departments, units and centres:Department of Pharmaceutics > Department of Pharmaceutics
ID Code:3240
Journal or Publication Title:European Journal of Pharmaceutical Sciences
Deposited By:Library Staff
Deposited On:17 May 2012 16:40
Last Modified:17 May 2012 16:40

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