A high sensitivity differential scanning calorimetry study of the interaction between poloxamers and dimyristoylphosphatidylcholine and dipalmitoylphosphatidylcholine liposomes

Castile, J, Taylor, K.M.G. and Buckton, G. (1999) A high sensitivity differential scanning calorimetry study of the interaction between poloxamers and dimyristoylphosphatidylcholine and dipalmitoylphosphatidylcholine liposomes. International Journal of Pharmaceutics, 182 (1). pp. 101-110. 10.1016/S0378-5173(99)00069-1.

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DOI: 10.1016/S0378-5173(99)00069-1

Abstract

High sensitivity differential scanning calorimetry (HSDSC) has been used to measure the thermal behaviour of dimyristoylphosphatidylcholine (DMPC) and dipalmitoylphosphatidylcholine (DPPC) liposomes to which poloxamer surfactants P338 or P407 had been added during or after preparation. The phospholipid pre-transition was more sensitive than the main transition to the association of poloxamers with liposomal bilayers. Poloxamers reduced the enthalpy of the pre-transition of liquid-crystalline state DMPC and DPPC MLVs but not that of gel state DPPC MLVs. Freezing and thawing DMPC and DPPC liposomes in the presence of poloxamers was shown to increase their interaction with the liposomal bilayers.

Item Type:Article
Uncontrolled Keywords:Freeze-thaw; High sensitivity differential scanning calorimetry; Liposome; Phase transition temperature; Phospholipid; Poloxamer; Surfactant
Departments, units and centres:Department of Pharmaceutics > Department of Pharmaceutics
ID Code:3242
Journal or Publication Title:International Journal of Pharmaceutics
Deposited By:Library Staff
Deposited On:17 May 2012 16:51
Last Modified:17 May 2012 16:51

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