Assessment of disorder in crystalline powders—a review of analytical techniques and their application

Buckton, G. and Darcy, P. (1999) Assessment of disorder in crystalline powders—a review of analytical techniques and their application. International Journal of Pharmaceutics, 179 (2). pp. 141-158. 10.1016/S0378-5173(98)00335-4.

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DOI: 10.1016/S0378-5173(98)00335-4

Abstract

The need to be able to measure amorphous contents in crystalline powders is now recognised. In this review, calorimetric and gravimetric methods are reviewed in a way that should alert workers in the field to the theoretical, and practical considerations which are important to understanding how best to study crystalline samples which contain low levels of amorphous material. It is shown that vapour sorption techniques are very powerful as long as serious consideration is given to the choice of environmental conditions and the exact experimental methodology. As the amount of published work in this field grows, it becomes increasingly necessary to describe experimental and data manipulation methods in great detail.

Item Type:Article
Uncontrolled Keywords:Amorphous; Microcalorimetry; Gravimetric sorption; Inverse phase gas chromatography; Near infra-red; Glass transition; Collapse
Departments, units and centres:Department of Pharmaceutics > Department of Pharmaceutics
ID Code:3243
Journal or Publication Title:International Journal of Pharmaceutics
Deposited By:Library Staff
Deposited On:17 May 2012 16:55
Last Modified:17 May 2012 16:55

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