Crystallisation of partially amorphous griseofulvin in water vapour: determination of kinetic parameters using isothermal heat conduction microcalorimetry

Ahmed, H., Buckton, G. and Rawlins, D.A. (1998) Crystallisation of partially amorphous griseofulvin in water vapour: determination of kinetic parameters using isothermal heat conduction microcalorimetry. International Journal of Pharmaceutics, 167 (1-2). p. 139. 10.1016/S0378-5173(98)00070-2.

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DOI: 10.1016/S0378-5173(98)00070-2

Abstract

Griseofulvin was made partiallyamorphous by storing at its melting point and then rapidly cooling. The partiallyamorphous sample was seen to have a different differential scanning calorimetry profile to the starting crystalline material. The powder X-ray diffraction pattern of the starting and quenched materials were very similar, however, some evidence of an amorphous halo was seen for the quenched sample. Exposure to 65, 75 or 85% relative humidity (RH) in an isothermal microcalorimeter yielded an exotherm which was shown to be due to crystallisation of the amorphous content of the drug. The exotherm was modelled as a solid state reaction process to allow calculation of the rate constant, we believe this is the first time that such an experiment has been modelled to allow calculation of a rate constant.

Item Type:Article
Uncontrolled Keywords:Crystallinity; Isothermal microcalorimetry; Griseofulvin; Thermodynamics; Kinetics; X-ray diffraction; Differential scanning calorimetry
Departments, units and centres:Department of Pharmaceutics > Department of Pharmaceutics
ID Code:3245
Journal or Publication Title:International Journal of Pharmaceutics
Deposited By:Library Staff
Deposited On:17 May 2012 17:29
Last Modified:17 May 2012 17:29

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