The use of thermal techniques to assess the impact of feed concentration on the amorphous content and polymorphic forms present in spray dried lactose

Chidavaenzi, O.C., Buckton, G., Koosha, F. and Pathak, R. (1997) The use of thermal techniques to assess the impact of feed concentration on the amorphous content and polymorphic forms present in spray dried lactose. International Journal of Pharmaceutics, 159 (1). p. 67. 10.1016/S0378-5173(97)00272-X.

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DOI: 10.1016/S0378-5173(97)00272-X


The influence of feed concentration (covering solutions and suspensions) on the physical forms of lactose obtained by spray drying was investigated. Isothermal microcalorimetry was used to assess the heats of crystallisation of the amorphous materials, which enabled the determination of the % amorphous content. Differential scanning calorimetry (DSC) provided qualitative data for the lactose polymorphs that were present in the spray dried products. Lactose monohydrate content was determined thermogravimetrically. The lactose which was dissolved was solidified as the amorphous form, due to the rapid drying conditions. The amorphous contents for the suspension feed concentrations were higher than the amount of lactose dissolved, which was due to a milling effect on the suspended lactose particles in the atomiser. The milling resulted in formation of amorphous material by solid state transition, or enhanced solubility or more likely a combination of both. Only the sample with the highest feed concentration contained small amounts of lactose monohydrate due to incomplete dehydration of the lactose in suspension. The presence of anhydrous lactose was due to the high inlet air temperatures causing dehydration of the lactose monohydrate which was in suspension. Variation of feed concentration during spray drying leads to products with different % amorphous contents and different proportions of crystalline forms. Beta lactose was not detected, either because it was absent or present in quantities below the detection limits of the thermal methods. The spray drying process is now better understood as a process that leads to loss of crystallinity in materials, possibly by a combination of rapid solidification of dissolved material and solid state transitions due to milling effects in the atomiser.

Item Type:Article
Uncontrolled Keywords:Amorphous; Polymorphism; Lactose; Spray drying; Crystallisation; Microcalorimetry; Differential scanning calorimetry; Thermogravimetric analysis
Departments, units and centres:Department of Pharmaceutics > Department of Pharmaceutics
ID Code:3248
Journal or Publication Title:International Journal of Pharmaceutics
Deposited By:Library Staff
Deposited On:18 May 2012 09:52
Last Modified:18 May 2012 09:52

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