Chawla, A., Buckton, G., Taylor, K.M.G., Newton, J.M. and Johnson, M.C.R. (1994) Wilhelmy plate contact angle data on powder compacts: considerations of plate perimeter. European Journal of Pharmaceutical Sciences, 2 (3). pp. 253-258. 10.1016/0928-0987(94)90030-2.
Full text not available from this repository.
A Wilhelmy plate method has been used to study the surface energies of spray-dried salbutamol sulphate. Scanning electron micrographs of compacts, prepared for the measurement of contact angles, revealed that the surfaces of the formed compacts were rough, and the lowest compression pressure left spheres of material over the surface of the compact. As the perimeter of the plate is an essential measurement for use in calculation of contact angles from Wilhelmy plates, estimates of the true perimeter have been made, and the results compared to those obtained by the use of the apparent external perimeter. On the basis of fractal geometry, the perimeter will increase in relation to the sensitivity of the measurement method, and in actual fact may be very significantly greater than the perceived external measurement. The effective perimeter must be considered for measurements of contact angle obtained by the Wilhelmy plate technique; unfortunately this is not readily estimated.
|Uncontrolled Keywords:||Key words; Contact angle; Wilhelmy plate; Surface energy; Powders; Fractal geometry; Polarity; Salbutamol|
|Departments, units and centres:||Department of Pharmaceutics > Department of Pharmaceutics|
|Journal or Publication Title:||European Journal of Pharmaceutical Sciences|
|Deposited By:||Library Staff|
|Deposited On:||18 May 2012 15:35|
|Last Modified:||18 May 2012 15:35|
Item downloaded times since 18 May 2012 15:35.
Repository Staff Only: Item control page
School of Pharmacy Staff Only: Edit a copy to replace this item