Constanti, A. and Sim, J.A. (1987) Muscarinic receptors mediating suppression of the M-current in guinea-pig olfactory cortex neurones may be of the M2-subtype. British Journal of Pharmacology, 90 (1). pp. 3-5.
Full text not available from this repository.
Guinea-pig olfactory cortical neurones in vitro were voltage clamped by means of a single intracellular microelectrode technique. Hyperpolarizing voltage commands from holding potentials between -40 to -50 mV produced slow inward current relaxations reflecting deactivation of the M-current (IM). IM was reversibly suppressed by 30 microM muscarine or carbachol; this suppression was insensitive to pirenzepine (up to 300 nM) but was inhibited by gallamine (10-20 microM) or 4-diphenyl-acetoxy-N-methylpiperidine (100, 500 nM), suggesting the involvement of the M2-type muscarinic receptor.
|Departments, units and centres:||Department of Pharmacology > Department of Pharmacology|
|Journal or Publication Title:||British Journal of Pharmacology|
|Deposited By:||Library Staff|
|Deposited On:||25 May 2012 10:29|
|Last Modified:||25 May 2012 10:29|
Item downloaded times since 25 May 2012 10:29.
Repository Staff Only: Item control page
School of Pharmacy Staff Only: Edit a copy to replace this item