Calcium-dependent action potentials and associated inward currents in guinea-pig neocortical neurons in vitro

Franz, P., Galban, M. and Constanti, A. (1986) Calcium-dependent action potentials and associated inward currents in guinea-pig neocortical neurons in vitro. Brain Research, 366 (1-2). pp. 262-271. 10.1016/0006-8993(86)91303-X.

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DOI: 10.1016/0006-8993(86)91303-X

Abstract

Calcium-dependent potential changes and inward currents were studied in guinea-pig neocortical neurons maintained in vitro. Under conditions of reduced outward potassium current, induced by external application of tetraethylammonium ions or internal application of cesium ions, regenerative Ca2+-dependent action potentials could be elicited. Strontium and barium ions could substitute for calcium as the charge carrier but not magnesium; cadmium blocked the calcium spikes. In caesium-loaded neurons, in the presence of tetrodotoxin and tetraethylammonium, inward currents were recorded when the membrane potential was step-polarized to potentials more positive than -50 mV. These currents were blocked by cadmium. It is concluded that guinea-pig neocortical neurons are capable of generating a calcium action potential via the activation of a slow inward current.

Item Type:Article
Departments, units and centres:Department of Pharmacology > Department of Pharmacology
ID Code:3300
Journal or Publication Title:Brain Research
Deposited By:Library Staff
Deposited On:25 May 2012 10:57
Last Modified:25 May 2012 10:57

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