Muscarinic depression of evoked surface-negative field potentials recorded from guinea-pig olfactory cortex in vitro

Williams, S.H., Constanti, A. and Brown, D.A. (1985) Muscarinic depression of evoked surface-negative field potentials recorded from guinea-pig olfactory cortex in vitro. Neuroscience Letters, 56 (3). pp. 301-306.

Full text not available from this repository.

Abstract

The action of some cholinergic drugs has been studied on the field potentials evoked by orthodromic stimulation of the lateral olfactory tract (LOT) in guinea-pig olfactory cortex slices maintained in vitro. A reversible depression of the electrically evoked surface-negative field potential (N-wave) was seen following superfusion of muscarine (10-200 μM) or mixed-agonist choline esters but not nicotinic agonists. This depression was blocked by atropine and pirenzepine, but not d-tubocurarine or by antagonists active at γ-aminobutyric acid or adenosine receptors. Little effect of muscarinic agonists was observed on the compound action potential recorded from the LOT, or on pial surface DC potential. A possible presynaptic site of action of muscarinic agonists in the olfactory cortex is discussed.

Item Type:Article
Departments, units and centres:Department of Pharmacology > Department of Pharmacology
ID Code:3301
Journal or Publication Title:Neuroscience Letters
Deposited By:Library Staff
Deposited On:25 May 2012 11:06
Last Modified:25 May 2012 11:06

Repository Staff Only: Item control page

School of Pharmacy Staff Only: Edit a copy to replace this item