Constanti, A., Galvan, M., Franz, P. and Sim, J.A. (1985) Calcium-dependent inward currents in voltage-clamped guinea-pig olfactory cortex neurones. Pfl�gers Archiv European Journal of Physiology, 404 (3). pp. 259-265. 10.1007/BF00581248.
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Guinea-pig olfactory cortex neurones in vitro (23°C-25°C) were voltage clamped by means of a single microelectrode sample-and-hold technique. In most Cs+-loaded neurones (in the presence of tetrodotoxin), membrane depolarization beyond -60mV elicited inward currents, which had rapid activation kinetics. The steady-state current-voltage relationship was N-shaped with a region of negative slope conductance between -50mV and -20mV. The rate of inactivation varied according to the holding potential and the command potential. The inward currents were maintained when external Ca2+ was replaced by Ba2+, and were blocked by Cd2+, suggesting that Ca2+ was the principal charge carrier. The results demonstrate the existence of calcium current in olfactory cortex neurones.
|Departments, units and centres:||Department of Pharmacology > Department of Pharmacology|
|Journal or Publication Title:||Pfl�gers Archiv European Journal of Physiology|
|Deposited By:||Library Staff|
|Deposited On:||25 May 2012 11:26|
|Last Modified:||25 May 2012 11:28|
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