Calcium-dependent inward currents in voltage-clamped guinea-pig olfactory cortex neurones

Constanti, A., Galvan, M., Franz, P. and Sim, J.A. (1985) Calcium-dependent inward currents in voltage-clamped guinea-pig olfactory cortex neurones. Pfl�gers Archiv European Journal of Physiology, 404 (3). pp. 259-265. 10.1007/BF00581248.

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DOI: 10.1007/BF00581248


Guinea-pig olfactory cortex neurones in vitro (23°C-25°C) were voltage clamped by means of a single microelectrode sample-and-hold technique. In most Cs+-loaded neurones (in the presence of tetrodotoxin), membrane depolarization beyond -60mV elicited inward currents, which had rapid activation kinetics. The steady-state current-voltage relationship was N-shaped with a region of negative slope conductance between -50mV and -20mV. The rate of inactivation varied according to the holding potential and the command potential. The inward currents were maintained when external Ca2+ was replaced by Ba2+, and were blocked by Cd2+, suggesting that Ca2+ was the principal charge carrier. The results demonstrate the existence of calcium current in olfactory cortex neurones.

Item Type:Article
Departments, units and centres:Department of Pharmacology > Department of Pharmacology
ID Code:3302
Journal or Publication Title:Pfl�gers Archiv European Journal of Physiology
Deposited By:Library Staff
Deposited On:25 May 2012 11:26
Last Modified:25 May 2012 11:28

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