Spontaneous inhibitory postsynaptic potentials in guinea pig neocortex and olfactory cortex neurones

Galvan, M., Franz, P. and Constanti, A. (1985) Spontaneous inhibitory postsynaptic potentials in guinea pig neocortex and olfactory cortex neurones. Neuroscience Letters, 57 (2). pp. 131-135. 10.1016/0304-3940(85)90051-5.

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DOI: 10.1016/0304-3940(85)90051-5

Abstract

The membrane potential of olfactory cortex and neocortex neurones in vitro was recorded using conventional microelectrode techniques. During recordings with KCl- or CsCl-filled microelectrodes, spontaneous, subthreshold, transient membrane depolarizations were observed. These were abolished by the GABA(A)-receptor antagonist, bicuculline methiodide, and were prolonged by the barbiturate pentobarbitone. In most cells they were abolished by tetrodotoxin. It is concluded that these spontaneous depolarizations are inhibitory postsynaptic potentials arising from spontaneous activity in inhibitory interneurones.

Item Type:Article
Departments, units and centres:Department of Pharmacology > Department of Pharmacology
ID Code:3303
Journal or Publication Title:Neuroscience Letters
Deposited By:Library Staff
Deposited On:25 May 2012 11:31
Last Modified:25 May 2012 11:31

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