Galvan, M., Constanti, A. and Franz, P. (1985) Calcium-dependent action potentials in guinea-pig olfactory cortex neurones. Pflugers Archiv European Journal of Physiology, 404 (3). pp. 252-258. 10.1007/BF00581247.
Full text not available from this repository.
Ca2+-dependent action potentials were recorded in guinea pig olfactory neurones in vitro (23°–25°C). In most cells (in the presence of tetrodotoxin: TTX) the current-voltage relationship displayed anomalous rectification (apparent high slope resistance) at potentials 20 mV depolarized to the resting membrane potential (–80 mV) and strong outward rectification at more positive potentials. Intracellular Cs+-loading blocked outward rectification and increased action potential duration. Such spikes were TTX-insensitive and were further prolonged by external addition of tetraethylammonium (TEA) or Ba2+. Spikes recorded from Cs+-loaded, TTX/TEA-treated neurones displayed a prolonged plateau and an after-depolarization. They persisted when Ba2+ or Sr2+ were substituted for external Ca2+, but not when Mg2+ was the sole extracellular divalent cation. The spikes were blocked in the presence of Cd2+ but persisted when 82% of the extracellular Na+ was substituted by choline. A TTX-insensitive, slowly inactivating inward current at depolarized potentials is believed to account for the subthreshold anomalous rectification and prolonged spike plateau.
|Uncontrolled Keywords:||Ca2+-dependent action potentials - Olfactory cortex neurones - Intracellular recording|
|Departments, units and centres:||Department of Pharmacology > Department of Pharmacology|
|Journal or Publication Title:||Pflugers Archiv European Journal of Physiology|
|Deposited By:||Library Staff|
|Deposited On:||25 May 2012 11:37|
|Last Modified:||25 May 2012 11:37|
Item downloaded times since 25 May 2012 11:37.
Repository Staff Only: Item control page
School of Pharmacy Staff Only: Edit a copy to replace this item