Calcium-dependent action potentials in guinea-pig olfactory cortex neurones

Galvan, M., Constanti, A. and Franz, P. (1985) Calcium-dependent action potentials in guinea-pig olfactory cortex neurones. Pflugers Archiv European Journal of Physiology, 404 (3). pp. 252-258. 10.1007/BF00581247.

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DOI: 10.1007/BF00581247


Ca2+-dependent action potentials were recorded in guinea pig olfactory neurones in vitro (23°–25°C). In most cells (in the presence of tetrodotoxin: TTX) the current-voltage relationship displayed anomalous rectification (apparent high slope resistance) at potentials 20 mV depolarized to the resting membrane potential (–80 mV) and strong outward rectification at more positive potentials. Intracellular Cs+-loading blocked outward rectification and increased action potential duration. Such spikes were TTX-insensitive and were further prolonged by external addition of tetraethylammonium (TEA) or Ba2+. Spikes recorded from Cs+-loaded, TTX/TEA-treated neurones displayed a prolonged plateau and an after-depolarization. They persisted when Ba2+ or Sr2+ were substituted for external Ca2+, but not when Mg2+ was the sole extracellular divalent cation. The spikes were blocked in the presence of Cd2+ but persisted when 82% of the extracellular Na+ was substituted by choline. A TTX-insensitive, slowly inactivating inward current at depolarized potentials is believed to account for the subthreshold anomalous rectification and prolonged spike plateau.

Item Type:Article
Uncontrolled Keywords:Ca2+-dependent action potentials - Olfactory cortex neurones - Intracellular recording
Departments, units and centres:Department of Pharmacology > Department of Pharmacology
ID Code:3304
Journal or Publication Title:Pflugers Archiv European Journal of Physiology
Deposited By:Library Staff
Deposited On:25 May 2012 11:37
Last Modified:25 May 2012 11:37

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