Presynaptic Cell Dependent Modulation of Inhibition in Cortical Regions

Ali, A.B. (2009) Presynaptic Cell Dependent Modulation of Inhibition in Cortical Regions. Neuropharmacology, 7 (2). pp. 125-131. 10.2174/157015909788848875.

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DOI: 10.2174/157015909788848875


Several lines of evidence suggest that the modulation of presynaptic GABA release is mediated by a variety of receptors including; presynaptic AMPA, cannabinoid, GABAB, kainate, metabotropic glutamate, NMDA, and opioid receptors. The evidence supporting presynaptic modulation of inhibition is predominantly obtained from studying stimulus elicited, spontaneous or miniature synaptic events, where the information regarding the identity of the presynaptic cell is lost. This article summarises these findings then focuses on another approach to study the presynaptic modulation of GABA release by comparing the modulation of GABA release at unitary synapses identified morphologically, immunocytochemically and electrophysiologically. To date, evidence for cell-type specific regulation of presynaptic inhibition at identified synapses involving most of the above presynaptic receptors does not exist. Therefore, the key presynaptic modulators that will be focused on here are kainate and cannabinoid receptors and their intracellular signalling cascades that orchestrate GABA release. There will be some discussion on presynaptic modulation via opioid receptors at identified synapses. This review provides evidence to suggest a cell-type specific modulation of presynaptic inhibition in cortical regions.

Item Type:Article
Uncontrolled Keywords:Presynaptic; inhibition; cortical; GABAA; cannabinoid receptor type-1 (CB1); kainate receptors; mGluRs; depolarisation induced suppression of inhibition
Departments, units and centres:Department of Pharmacology > Department of Pharmacology
ID Code:3313
Journal or Publication Title:Neuropharmacology
Deposited By:Library Staff
Deposited On:31 May 2012 12:20
Last Modified:31 May 2012 12:20

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