A novel protein, amyloid precursor-like protein 2, is present in human brain, cerebrospinal fluid and conditioned media

Webster, M-T., Groome, N., Francis, P.T., Pearce, B.R., Sherriff, F.E., Thinakaran, G., Felsenstein, K.M., Wasco, W., Tanzi, R.E. and Bowen, D.M. (1995) A novel protein, amyloid precursor-like protein 2, is present in human brain, cerebrospinal fluid and conditioned media. Biochemical Journal, 310 (1). pp. 95-99.

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Abstract

A monoclonal antibody, 3B11, was raised to a novel protein, amyloid precursor-like protein 2, which did not recognize amyloid precursor protein. Multiple bands were detected in human brain fractions and cell lysate by Western blotting, indicating the presence of isoforms. 3B11 immunoreactivity was also detected in cerebrospinal fluid and conditioned medium, indicating that the protein is secreted. Immunocytochemistry revealed 3B11 immunoreactivity in sections of human brain.

Item Type:Article
Departments, units and centres:Department of Pharmacology > Department of Pharmacology
ID Code:3328
Journal or Publication Title:Biochemical Journal
Deposited By:Library Staff
Deposited On:31 May 2012 17:19
Last Modified:31 May 2012 17:19

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