Gibbons, S., Leimkugel, J. and Heinrich, M. (2003) Activity of Zanthoxylum clava-herculis extracts against multidrug resistant methicillin resistant Staphylococcus aureus (mdr-MRSA). Phytotherapy Research, 17 (3). pp. 274-275. 10.1002/ptr.1112.
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DOI: 10.1002/ptr.1112
Abstract
In a continuing search for compounds with antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA) possessing multidrug efflux systems, we have demonstrated activity associated with extracts from Southern prickly ash bark, Zanthoxylum clava-herculis. Bioassay-guided isolation of an alkaloid extract led to the characterization of the benzo[c]phenanthridine alkaloid chelerythrine as the major active principle. This compound exhibited potent activity against strains of MRSA, which were highly resistant to clinically useful antibiotics via multidrug efflux mechanisms.
| Item Type: | Article |
|---|---|
| Additional Information: | Full text available in print and electronically at the School of Pharmacy Library. |
| Departments, units and centres: | Department of Pharmaceutical and Biological Chemistry > Centre for Pharmacognosy and Phytotherapy |
| ID Code: | 384 |
| Journal or Publication Title: | Phytotherapy Research |
| Deposited By: | Library Staff |
| Deposited On: | 04 Sep 2007 |
| Last Modified: | 07 Oct 2011 13:20 |
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