Gibbons, S., Leimkugel, J. and Heinrich, M. (2003) Activity of Zanthoxylum clava-herculis extracts against multidrug resistant methicillin resistant Staphylococcus aureus (mdr-MRSA). Phytotherapy Research, 17 (3). pp. 274-275. 10.1002/ptr.1112.
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In a continuing search for compounds with antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA) possessing multidrug efﬂux systems, we have demonstrated activity associated with extracts from Southern prickly ash bark, Zanthoxylum clava-herculis. Bioassay-guided isolation of an alkaloid extract led to the characterization of the benzo[c]phenanthridine alkaloid chelerythrine as the major active principle. This compound exhibited potent activity against strains of MRSA, which were highly resistant to clinically useful antibiotics via multidrug efﬂux mechanisms.
|Additional Information:||Full text available in print and electronically at the School of Pharmacy Library.|
|Departments, units and centres:||Department of Pharmaceutical and Biological Chemistry > Centre for Pharmacognosy and Phytotherapy|
|Journal or Publication Title:||Phytotherapy Research|
|Deposited By:||Library Staff|
|Deposited On:||04 Sep 2007|
|Last Modified:||07 Oct 2011 13:20|
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