Activity of Zanthoxylum clava-herculis extracts against multidrug resistant methicillin resistant Staphylococcus aureus (mdr-MRSA)

Gibbons, S., Leimkugel, J. and Heinrich, M. (2003) Activity of Zanthoxylum clava-herculis extracts against multidrug resistant methicillin resistant Staphylococcus aureus (mdr-MRSA). Phytotherapy Research, 17 (3). pp. 274-275. 10.1002/ptr.1112.

Full text not available from this repository.

DOI: 10.1002/ptr.1112

Abstract

In a continuing search for compounds with antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA) possessing multidrug efflux systems, we have demonstrated activity associated with extracts from Southern prickly ash bark, Zanthoxylum clava-herculis. Bioassay-guided isolation of an alkaloid extract led to the characterization of the benzo[c]phenanthridine alkaloid chelerythrine as the major active principle. This compound exhibited potent activity against strains of MRSA, which were highly resistant to clinically useful antibiotics via multidrug efflux mechanisms.

Item Type:Article
Additional Information:Full text available in print and electronically at the School of Pharmacy Library.
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Centre for Pharmacognosy and Phytotherapy
ID Code:384
Journal or Publication Title:Phytotherapy Research
Deposited By:Library Staff
Deposited On:04 Sep 2007
Last Modified:07 Oct 2011 13:20

Repository Staff Only: Item control page

School of Pharmacy Staff Only: Edit a copy to replace this item