Galanthamine from snowdrop: the development of a modern drug against Alzheimer's disease from local Caucasian knowledge

Heinrich, M. (2004) Galanthamine from snowdrop: the development of a modern drug against Alzheimer's disease from local Caucasian knowledge. Journal of Ethnopharmacology, 92 (2-3). pp. 147-162. 10.1016/j.jep.2004.02.012,.

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DOI: 10.1016/j.jep.2004.02.012,

Abstract

In recent years, galanthamine isolated from several members of the Amaryllidaceae (Leucojum spp., Narcissus species, Galanthus spp.) has become an important therapeutic options used to slow down the process of neurological degeneration in Alzheimer's disease. This review traces aspects of the history of its development from little known observational studies in the Caucasus Mountains (Southern Russia), to the use of this drug in Eastern European countries (esp. Bulgaria) in the treatment of poliomyelitis and ultimately to the recent introduction onto Western markets in the treatment of Alzheimer's disease. Of note, little is known about the early history of the drug's development and the review also points to other gaps in our knowledge about the ethnopharmacology, pharmacology and clinical use of galanthamine.

Item Type:Article
Additional Information:Full text available in print and electronically at the School of Pharmacy Library.
Uncontrolled Keywords: Drug discovery; Galanthamine; Galanthus worwonowii; Leucojum aestivum; Narcissus pseudonarcissus; Alzheimer’s; Poliomyelitis; Bulgaria; Caucasus Mountains (Russia); Clinical study
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Centre for Pharmacognosy and Phytotherapy
ID Code:398
Journal or Publication Title:Journal of Ethnopharmacology
Deposited By:Library Staff
Deposited On:24 Nov 2006
Last Modified:19 Jan 2012 14:50

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