Fiebich, B.L., Heinrich, M., Hiller, K.O. and Kammerer, N. (2001) Inhibition of TNF-a synthesis in LPS-stimulated primary human monocytes by Harpagophytum extract SteiHap69. Phytomedicine, 8 (1). pp. 28-30. 10.1078/0944-7113-00002.
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Harpagophytum procumbens (Devil's Claw) is often used in the supportive treatment of inflammatory and degenerative diseases of the skeletal system. Here we studied the anti-inflammatory properties of the Harpagophytum extract SteiHap 69 (Steiner Harpagophytum procumbens extract 69) on primary human monocytes, a useful model of peripheral inflammation. After eliminating lipopolysaccharides of bacterial origin, SteiHap 69 prevented the LPS-induced synthesis of tumour necrosis factor alpha (TNFα) in stimulated primary human monocytes in a dose-dependent manner. Harpagide and harpagoside had no effect on LPS-induced TNFα-release. Our data provides evidence that the Harpagophytum extract SteiHap 69 has anti-inflammatory properties. Further studies are required in order to elucidate the molecular mechanism of Devil's claw anti-inflammatory effects.
|Additional Information:||Full text available in print and electronically at the School of Pharmacy Library.|
|Uncontrolled Keywords:||Harpagophytum procumbens extract; harpagoside; harpagide; antiinflammatory properties; rheumatic diseases; cytokines; protaglandins; human monocytes; TNF-alpha inhibition|
|Departments, units and centres:||Department of Pharmaceutical and Biological Chemistry > Centre for Pharmacognosy and Phytotherapy|
|Journal or Publication Title:||Phytomedicine|
|Deposited By:||Library Staff|
|Deposited On:||30 Aug 2007|
|Last Modified:||07 Oct 2011 11:52|
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