Inhibition of TNF-a synthesis in LPS-stimulated primary human monocytes by Harpagophytum extract SteiHap69

Fiebich, B.L., Heinrich, M., Hiller, K.O. and Kammerer, N. (2001) Inhibition of TNF-a synthesis in LPS-stimulated primary human monocytes by Harpagophytum extract SteiHap69. Phytomedicine, 8 (1). pp. 28-30. 10.1078/0944-7113-00002.

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DOI: 10.1078/0944-7113-00002

Abstract

Harpagophytum procumbens (Devil's Claw) is often used in the supportive treatment of inflammatory and degenerative diseases of the skeletal system. Here we studied the anti-inflammatory properties of the Harpagophytum extract SteiHap 69 (Steiner Harpagophytum procumbens extract 69) on primary human monocytes, a useful model of peripheral inflammation. After eliminating lipopolysaccharides of bacterial origin, SteiHap 69 prevented the LPS-induced synthesis of tumour necrosis factor alpha (TNFα) in stimulated primary human monocytes in a dose-dependent manner. Harpagide and harpagoside had no effect on LPS-induced TNFα-release. Our data provides evidence that the Harpagophytum extract SteiHap 69 has anti-inflammatory properties. Further studies are required in order to elucidate the molecular mechanism of Devil's claw anti-inflammatory effects.

Item Type:Article
Additional Information:Full text available in print and electronically at the School of Pharmacy Library.
Uncontrolled Keywords: Harpagophytum procumbens extract; harpagoside; harpagide; antiinflammatory properties; rheumatic diseases; cytokines; protaglandins; human monocytes; TNF-alpha inhibition
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Centre for Pharmacognosy and Phytotherapy
ID Code:405
Journal or Publication Title:Phytomedicine
Deposited By:Library Staff
Deposited On:30 Aug 2007
Last Modified:07 Oct 2011 11:52

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