Fiebich, B.L., Heinrich, M., Hiller, K.O. and Kammerer, N. (2001) Inhibition of TNF-a synthesis in LPS-stimulated primary human monocytes by Harpagophytum extract SteiHap69. Phytomedicine, 8 (1). pp. 28-30. 10.1078/0944-7113-00002.
Full text not available from this repository.
Abstract
Harpagophytum procumbens (Devil's Claw) is often used in the supportive treatment of inflammatory and degenerative diseases of the skeletal system. Here we studied the anti-inflammatory properties of the Harpagophytum extract SteiHap 69 (Steiner Harpagophytum procumbens extract 69) on primary human monocytes, a useful model of peripheral inflammation. After eliminating lipopolysaccharides of bacterial origin, SteiHap 69 prevented the LPS-induced synthesis of tumour necrosis factor alpha (TNFα) in stimulated primary human monocytes in a dose-dependent manner. Harpagide and harpagoside had no effect on LPS-induced TNFα-release. Our data provides evidence that the Harpagophytum extract SteiHap 69 has anti-inflammatory properties. Further studies are required in order to elucidate the molecular mechanism of Devil's claw anti-inflammatory effects.
| Item Type: | Article |
|---|---|
| Additional Information: | Full text available in print and electronically at the School of Pharmacy Library. |
| Uncontrolled Keywords: | Harpagophytum procumbens extract; harpagoside; harpagide; antiinflammatory properties; rheumatic diseases; cytokines; protaglandins; human monocytes; TNF-alpha inhibition |
| Departments, units and centres: | Department of Pharmaceutical and Biological Chemistry > Centre for Pharmacognosy and Phytotherapy |
| ID Code: | 405 |
| Journal or Publication Title: | Phytomedicine |
| Deposited By: | Library Staff |
| Deposited On: | 30 Aug 2007 |
| Last Modified: | 07 Oct 2011 11:52 |
Statistics
Item downloaded times since 30 Aug 2007.
Repository Staff Only: Item control page
School of Pharmacy Staff Only: Edit a copy to replace this item