Backhouse, L., Dias, M., Gorce, J.P., Hadgraft, J., McDonald, P.J. and Wiechers, J.W. (2004) GARField magnetic resonance profiling of the ingress of model skin-care ingredients into human skin in vitro. Journal of Pharmaceutical Sciences, 93 (9). pp. 2274-2283. 10.1002/jps.20137.
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A preliminary study of the ingress of mineral oil, decanol, and glycerine into samples of human abdominal skin tissue in vitro made using magnetic resonance profiling with a GARField magnet is reported. Two layers, each circa 50 μm thick and attributed to stratum corneum and viable epidermis, are spatially resolved. Clear differences are observed in the magnetic resonance response of these layers arising from the application of the model skin-care product ingredients. In the case of decanol and glycerine, it is suggested that the profiles show evidence for the effects of moisturization, as distinct from hydration. In the case of glycerine, the effective ingress diffusion coefficient is calculated to be 1.3 ± 0.5 × 10−9 cm2s−1
|Additional Information:||Full text available in print and electronically at the School of Pharmacy Library.|
|Uncontrolled Keywords:||skin;NMR;imaging methods;diffusion|
|Departments, units and centres:||Department of Pharmaceutics > Department of Pharmaceutics|
|Journal or Publication Title:||Journal of Pharmaceutical Sciences|
|Deposited By:||Library Staff|
|Deposited On:||22 Jan 2007|
|Last Modified:||03 Nov 2011 10:32|
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